Increased extracellular levels of ascorbate in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis.
Neurosci Lett
; 95(1-3): 286-90, 1988 Dec 19.
Article
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| MEDLINE
| ID: mdl-3226614
ABSTRACT
Extracellular (EC) ascorbate concentrations were measured in microdialysates from the striatum bilaterally in rats subjected to unilateral middle cerebral artery occlusion (MCAO). The focal cerebral ischemia induced a dramatic increase in ascorbate on the ipsilateral (operated) side while the levels remained at the preocclusion level in the striatum of the contralateral (control) hemisphere. The possibility that ascorbate may aggravate ischemic neuronal damage by its proposed neuromodulatory properties and/or by its ability to induce lipid peroxidation is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Ascórbico
/
Ataque Isquémico Transitorio
/
Cuerpo Estriado
/
Espacio Extracelular
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1988
Tipo del documento:
Article
País de afiliación:
Suecia