Synthesis, biological activity, molecular docking studies of a novel series of 3-Aryl-7<i>H</i>-thiazolo[3,2-<i>b</i>]-1,2,4-triazin-7-one derivatives as the acetylcholinesterase inhibitors.

Jin, Zhe; Zhang, Chao; Liu, Miao; Jiao, Simeng; Zhao, Jing; Liu, Xiaoping; Lin, Huangquan; Chi-Cheong Wan, David; Hu, Chun

Synthesis, biological activity, molecular docking studies of a novel series of 3-Aryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the acetylcholinesterase inhibitors.

Jin, Zhe; Zhang, Chao; Liu, Miao; Jiao, Simeng; Zhao, Jing; Liu, Xiaoping; Lin, Huangquan; Chi-Cheong Wan, David; Hu, Chun.

Afiliación

Jin Z; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Zhang C; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Liu M; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Jiao S; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Zhao J; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Liu X; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
Lin H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Chi-Cheong Wan D; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hu C; Key Laboratory of Structure-based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.

J Biomol Struct Dyn ; 39(7): 2478-2489, 2021 Apr.

Article en En | MEDLINE | ID: mdl-32266865

Asunto(s)

Acetilcolinesterasa; Inhibidores de la Colinesterasa; Acetilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacología; Diseño de Fármacos; Humanos; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad; Tiazoles; Triazinas

Palabras clave

Acetylcholinesterase Inhibitor; Docking; Heterocycle; SAR; Synthesis; Thiazolo[3,2-b]-1,2,4-triazine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Inhibidores de la Colinesterasa Límite: Humans Idioma: En Revista: J Biomol Struct Dyn Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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