Your browser doesn't support javascript.
loading
E-cadherin deregulation in breast cancer.
Corso, Giovanni; Figueiredo, Joana; De Angelis, Simone Pietro; Corso, Federica; Girardi, Antonia; Pereira, Joana; Seruca, Raquel; Bonanni, Bernardo; Carneiro, Patricia; Pravettoni, Gabriella; Guerini Rocco, Elena; Veronesi, Paolo; Montagna, Giacomo; Sacchini, Virgilio; Gandini, Sara.
Afiliación
  • Corso G; Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy.
  • Figueiredo J; Department of Oncology and Hemato-Oncology, Faculty of Medicine, University of Milan, Milan, Italy.
  • De Angelis SP; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Corso F; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Girardi A; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Pereira J; Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy.
  • Seruca R; Division of Breast Surgery, European Institute of Oncology IRCCS, Milan, Italy.
  • Bonanni B; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Carneiro P; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Pravettoni G; Faculty of Medicine, University of Porto, Porto, Portugal.
  • Guerini Rocco E; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Veronesi P; IPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
  • Montagna G; Faculty of Medicine, University of Porto, Porto, Portugal.
  • Sacchini V; Division of Cancer Prevention and Genetics, European Institute of Oncology IRCCS, Milan, Italy.
  • Gandini S; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
J Cell Mol Med ; 24(11): 5930-5936, 2020 06.
Article en En | MEDLINE | ID: mdl-32301282
ABSTRACT
E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cadherinas / Regulación Neoplásica de la Expresión Génica Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cadherinas / Regulación Neoplásica de la Expresión Génica Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Italia