Linezolid and fentanyl: An underrecognized drug-to-drug interaction.
J Clin Pharm Ther
; 45(4): 825-827, 2020 Aug.
Article
en En
| MEDLINE
| ID: mdl-32304579
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Despite its frequent use in clinical practice, fentanyl's pro-serotonergic effects are underrecognized, especially in combination with linezolid. Life-threatening reactions can occur. CASESUMMARY:
We report a case of serotonin syndrome developed shortly after the initiation of linezolid in a 63-year-old patient in whom selective serotonin reuptake inhibitor therapy was discontinued for the duration of antibiotic therapy. However, fentanyl transdermal patch treatment was inadvertently continued. Noteworthy, 24 hours following discontinuation of linezolid, the patient experienced complete resolution of symptoms. WHAT IS NEW ANDCONCLUSION:
Fentanyl can increase the intrasynaptic release of serotonin through their effects on y-amino butyric acid and its phenylpiperidine chemical structure. We illustrate the importance of thorough medication reconciliation and review of all potential drug-to-drug interactions when indicating linezolid therapy to ensure patient safety. We believe that our case provides novel observations and insight that could help recognize similar cases in clinical practice.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fentanilo
/
Síndrome de la Serotonina
/
Linezolid
Límite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2020
Tipo del documento:
Article