Interface dermatitis as an indicator of hepatic involvement in drug reaction with eosinophilia and systemic symptoms (DRESS).
J Cutan Pathol
; 47(9): 800-808, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-32310304
ABSTRACT
BACKGROUND:
There are conflicting reports on the association between interface dermatitis and hepatic involvement in DRESS.METHODS:
A cross-sectional analysis of the clinical and the histopathologic features of DRESS was performed to study the association between the histopathology of the skin rash and hepatic involvement.RESULTS:
The clinical and the histopathologic findings were evaluated in 40 cases of DRESS. Thirty patients (75%) had a hepatic involvement. Thirty (75%) biopsy specimens showed a combination of different inflammatory patterns. The interface dermatitis was noted in 24 specimens (60%). Twenty-one patients with the interface dermatitis had a hepatic involvement (P = .04).CONCLUSIONS:
The skin rash of DRESS often shows the coexistence of different inflammatory patterns. The interface dermatitis showed a statistically significant association with the hepatic involvement in DRESS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dermatitis
/
Eosinofilia
/
Exantema
/
Síndrome de Hipersensibilidad a Medicamentos
/
Hígado
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Cutan Pathol
Año:
2020
Tipo del documento:
Article
País de afiliación:
India