The Z&#945;2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.

Kesavardhana, Sannula; Malireddi, R K Subbarao; Burton, Amanda R; Porter, Shaina N; Vogel, Peter; Pruett-Miller, Shondra M; Kanneganti, Thirumala-Devi

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.

Kesavardhana, Sannula; Malireddi, R K Subbarao; Burton, Amanda R; Porter, Shaina N; Vogel, Peter; Pruett-Miller, Shondra M; Kanneganti, Thirumala-Devi.

Afiliación

Kesavardhana S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Malireddi RKS; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Burton AR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Porter SN; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Vogel P; Animal Resources Center and Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pruett-Miller SM; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA Thirumala-Devi.Kanneganti@StJude.org.

J Biol Chem ; 295(24): 8325-8330, 2020 06 12.

Article en En | MEDLINE | ID: mdl-32350114

Asunto(s)

Pérdida del Embrión/patología; Desarrollo Embrionario; Necroptosis; Infecciones por Orthomyxoviridae/metabolismo; Infecciones por Orthomyxoviridae/patología; Piroptosis; Proteínas de Unión al ARN/química; Proteínas de Unión al ARN/metabolismo; Secuencia de Aminoácidos; Animales; Humanos; Inflamasomas/metabolismo; Gripe Humana/metabolismo; Gripe Humana/patología; Ratones Endogámicos C57BL; Dominios Proteicos; Eliminación de Secuencia

Palabras clave

RNA virus; infection; influenza; influenza virus; microbiology; negative-strand RNA virus

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Infecciones por Orthomyxoviridae / Desarrollo Embrionario / Pérdida del Embrión / Piroptosis / Necroptosis Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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