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Difference in biophysical properties of cancer-initiating cells in melanoma mutated zebrafish.
Makarova, N; Kalaparthi, Vivek; Wang, Andrew; Williams, Chris; Dokukin, M E; Kaufman, Charles K; Zon, Leonard; Sokolov, I.
Afiliación
  • Makarova N; Department of Mechanical Engineering, Tufts University, Medford, MA, USA.
  • Kalaparthi V; Department of Mechanical Engineering, Tufts University, Medford, MA, USA.
  • Wang A; Department of Mechanical Engineering, Tufts University, Medford, MA, USA.
  • Williams C; Department of Mechanical Engineering, Tufts University, Medford, MA, USA.
  • Dokukin ME; Department of Mechanical Engineering, Tufts University, Medford, MA, USA; Sarov Physics and Technology Institute, National Research Nuclear University MEPhI, Sarov, Russian Federation.
  • Kaufman CK; Department of Medicine, Division of Oncology, Washington University, St. Louis, MO, USA.
  • Zon L; Boston Children's Hospital, Boston, MA, USA.
  • Sokolov I; Department of Mechanical Engineering, Tufts University, Medford, MA, USA; Department of Biomedical Engineering, Tufts University, Medford, MA, USA; Department of Physics, Tufts University, Medford, MA, USA. Electronic address: igor.sokolov@tufts.edu.
J Mech Behav Biomed Mater ; 107: 103746, 2020 07.
Article en En | MEDLINE | ID: mdl-32364948
ABSTRACT
Despite sharing oncogenetic mutations, only a small number of cells within a given tissue will undergo malignant transformation. Biochemical and physical factors responsible for this cancer-initiation process are not well understood. Here we study biophysical differences of pre-melanoma and melanoma cells in a BRAFV600E/P53 zebrafish model. The AFM indentation technique was used to study the cancer-initiating cells while the surrounding melanocytes were the control. We observed a statistically significant decrease in the modulus of elasticity (the effective Young's modulus) of cancer-initiating cells compared to the surrounding melanocytes. No significant differences in the pericellular coat surrounding cells were observed. These results contribute to a better understanding of the factors responsible for the initiation of cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Mech Behav Biomed Mater Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos