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Preoperative Neutrophil-to-lymphocyte Ratio Predicts Tumor-infiltrating CD8+ T Cells in Biliary Tract Cancer.
Tanaka, Ryota; Kimura, Kenjiro; Eguchi, Shinpei; Tauchi, Jun; Shibutani, Masatune; Shinkawa, Hiroji; Ohira, G O; Yamazoe, Sadaaki; Tanaka, Shogo; Amano, Ryosuke; Tanaka, Hiroaki; Yashiro, Masakazu; Kubo, Shoji; Ohira, Masaichi.
Afiliación
  • Tanaka R; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kimura K; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan kenjiro@med.osaka-cu.ac.jp.
  • Eguchi S; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Tauchi J; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Shibutani M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Shinkawa H; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Ohira GO; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Yamazoe S; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Tanaka S; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Amano R; Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Tanaka H; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Yashiro M; Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kubo S; Molecular Oncology and Therapeutics, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Ohira M; Cancer Center for Translational Research, Osaka City University Graduate School of Medicine, Osaka, Japan.
Anticancer Res ; 40(5): 2881-2887, 2020 May.
Article en En | MEDLINE | ID: mdl-32366438
ABSTRACT
BACKGROUND/

AIM:

This study evaluated the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) and CD8+ tumor-infiltrating lymphocytes (TILs), and whether preoperative NLR was associated with CD8+ TILs in biliary tract cancers (BTCs). PATIENTS AND

METHODS:

A total of 154 patients with BTCs who underwent surgery were enrolled in this study. We obtained neutrophil and lymphocyte counts, and calculated NLR from preoperative peripheral blood samples. CD8+ TILs were identified by immunohistochemical staining.

RESULTS:

The overall survival (OS) and recurrence-free survival (RFS) of patients with high NLR were shorter than those with low NLR. The OS and RFS of patients with high CD8+ TILs were longer than those with low CD8+ TILs. Preoperative NLR and CD8+ TILs were negatively correlated.

CONCLUSION:

NLR and CD8+ TILs were associated with OS and RFS in BTCs. NLR can predict CD8+ TILs infiltrating the cancer microenvironment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Biliar / Linfocitos / Linfocitos Infiltrantes de Tumor / Linfocitos T CD8-positivos / Neutrófilos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Anticancer Res Año: 2020 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Biliar / Linfocitos / Linfocitos Infiltrantes de Tumor / Linfocitos T CD8-positivos / Neutrófilos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: Anticancer Res Año: 2020 Tipo del documento: Article País de afiliación: Japón