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Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.
Sharifi, Roohollah; Jahedi, Sajjad; Mozaffari, Hamid Reza; Imani, Mohammad Moslem; Sadeghi, Masoud; Golshah, Amin; Moradpoor, Hedaiat; Safaei, Mohsen.
Afiliación
  • Sharifi R; Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
  • Jahedi S; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran.
  • Mozaffari HR; Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
  • Imani MM; Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
  • Sadeghi M; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran. sadeghi_mbrc@yahoo.com.
  • Golshah A; Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
  • Moradpoor H; Department of Prosthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
  • Safaei M; Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, 6713954658, Iran.
BMC Oral Health ; 20(1): 132, 2020 05 06.
Article en En | MEDLINE | ID: mdl-32375748
ABSTRACT

BACKGROUND:

This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility.

METHODS:

We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software.

RESULTS:

A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group.

CONCLUSIONS:

The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de la Matriz Extracelular / Polimorfismo de Nucleótido Simple / Caries Dental / Susceptibilidad a Caries Dentarias / Amelogenina / Lactoferrina Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: BMC Oral Health Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de la Matriz Extracelular / Polimorfismo de Nucleótido Simple / Caries Dental / Susceptibilidad a Caries Dentarias / Amelogenina / Lactoferrina Tipo de estudio: Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: BMC Oral Health Asunto de la revista: ODONTOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Irán