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Placental expression of leptin: fetal sex-independent relation with human placental growth.
Kochhar, P; Manikandan, C; Ravikumar, G; Dwarkanath, P; Sheela, C N; George, S; Thomas, A; Crasta, J; Thomas, T; Kurpad, A V; Mukhopadhyay, A.
Afiliación
  • Kochhar P; Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
  • Manikandan C; Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
  • Ravikumar G; School of Biosciences and Technology; Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology, Vellore, India.
  • Dwarkanath P; Department of Pathology, St John's Medical College Hospital, Bangalore, India.
  • Sheela CN; Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
  • George S; Department of Obstetrics and Gynaecology, St John's Medical College Hospital, Bangalore, India.
  • Thomas A; Department of Obstetrics and Gynaecology, St John's Medical College Hospital, Bangalore, India.
  • Crasta J; Department of Obstetrics and Gynaecology, St John's Medical College Hospital, Bangalore, India.
  • Thomas T; Department of Pathology, St John's Medical College Hospital, Bangalore, India.
  • Kurpad AV; Department of Biostatistics, St. John's Medical College Hospital, Bangalore, India.
  • Mukhopadhyay A; Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.
Eur J Clin Nutr ; 74(11): 1603-1612, 2020 11.
Article en En | MEDLINE | ID: mdl-32382074
OBJECTIVES: Leptin (LEP) is a vital placental hormone that is known to affect different aspects of placental function and fetal development. The present study aimed to determine the association of placental LEP transcript abundance with maternal, placental, and newborn parameters. SUBJECTS/METHODS: In this retrospective case-control study, placental samples (n = 105) were collected from small (SGA) and appropriate (AGA) for gestational age full-term singleton pregnancies (n = 44 SGA and n = 61 AGA). Placental transcript abundance of LEP was assessed by real-time quantitative PCR after normalization to a reference gene panel. LEP methylation was measured using a quantitative MethyLight assay in a subset of samples (n = 54). RESULTS: Placental LEP transcript abundance was negatively and significantly associated with placental weight (ß = -3.883, P = 0.015). This association continued to be significant in the SGA group (ß = -10.332, P = 0.001), both in female (ß = -15.423, P = 0.021) and male births (ß = -10.029, P = 0.007). LEP transcript abundance was not associated with LEP methylation levels (Spearman's ρ = 0.148, P = 0.287). CONCLUSION: We conclude that placental upregulation of LEP is an integral and fetal sex-independent component of placental growth restriction, which can be potentially targeted through maternal dietary modifications to improve fetoplacental growth.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Leptina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Placenta / Leptina Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Eur J Clin Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido