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Paclitaxel-terminated peptide brush polymers.
Zhu, Jialei; Sun, Hao; Callmann, Cassandra E; Thompson, Matthew P; Battistella, Claudia; Proetto, Maria T; Carlini, Andrea S; Gianneschi, Nathan C.
Afiliación
  • Zhu J; Institute of Chemical Biology and Nanomedicine, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China.
  • Sun H; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Callmann CE; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Thompson MP; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Battistella C; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Proetto MT; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Carlini AS; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
  • Gianneschi NC; Departments of Chemistry, Materials Science & Engineering, Pharmacology, and Biomedical Engineering, International Institute for Nanotechnology, Chemistry of Life Processes Institute, and Simpson Querrey Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Chem Commun (Camb) ; 56(50): 6778-6781, 2020 Jun 23.
Article en En | MEDLINE | ID: mdl-32441281
ABSTRACT
In this paper, we report the preparation of paclitaxel-terminated peptide brush polymers wherein cell uptake and toxicity are tunable based on peptide sequence. Synthesis was enabled using a new paclitaxel-containing chain termination agent for ring-opening metathesis polymerization (ROMP). Critically, reverse phase HPLC could be used to efficiently separate peptide brush polymers consisting of one fluorophore and one terminal paclitaxel from crude polymer mixtures. These purified terminally-modified polymers showed greater potency than the original mixtures. Drug-terminated peptide brush polymers carrying positive charges exhibited enhanced cell uptake and cytotoxicity as compared to their neutral and negatively charged analogues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Polímeros / Paclitaxel / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Polímeros / Paclitaxel / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China