Limonoids from Cipadessa baccifera.
J Nat Prod
; 83(6): 1751-1765, 2020 06 26.
Article
en En
| MEDLINE
| ID: mdl-32468815
ABSTRACT
Eighteen new limonoids, including eight methyl angolensates (1-8) and 10 cipadesins (9-18), were isolated from the leaves of Cipadessa baccifera. Their structures were characterized by means of spectroscopic data analyses, single-crystal X-ray diffraction, and quantum chemistry computational methods. The C-6 configurations in those compounds possessing a C-6 hydroxy group were all assigned as S regardless of the magnitude of J5,6, and the C-2' configuration in those bearing a 2-methylbutyryl residue was defined by single-crystal X-ray diffraction and NMR data. Compounds 1, 5, 6, 7, 11, and 12 showed moderate antimalarial activities with IC50 values ranging from 12 to 28 µM.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Meliaceae
/
Limoninas
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2020
Tipo del documento:
Article