NH4I-Triggered [4 + 2] Annulation of α,ß-Unsaturated Ketoxime Acetates with N-Acetyl Enamides for the Synthesis of Pyridines.
J Org Chem
; 85(12): 8157-8165, 2020 06 19.
Article
en En
| MEDLINE
| ID: mdl-32478514
The NH4I-triggered formal [4 + 2] annulation of α,ß-unsaturated ketoxime acetates with N-acetyl enamides has been developed. The current protocol employs electron-rich enamides as C2 synthons and enables the efficient and straightforward construction of polysubstituted pyridines in moderate to good yields based on metal-free systems. The reaction tolerates a wide range of functional groups and represents an alternate route toward the synthesis of pyridine derivatives.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2020
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos