The role of suvorexant in the prevention of delirium during acute hospitalization: A systematic review.
J Crit Care
; 59: 1-5, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-32480359
ABSTRACT
PURPOSE:
To assess the efficacy and safety of suvorexant for the prevention of delirium during acute hospitalization. MATERIALS ANDMETHODS:
Pubmed (1946 to December 2019) and Embase (1947 to December 2019) were queried using the search term combination delirium, confusion, cognitive defect, encephalopathy, critically ill patient, critical illness, or hospitalization and suvorexant or orexin receptor antagonist. Studies analyzed for relevance evaluated clinical outcomes of patients treated with suvorexant for prevention of delirium. Studies appropriate to the objective were evaluated, including two randomized controlled trials and four retrospective studies.RESULTS:
In acutely hospitalized patients, treatment with suvorexant 15 to 20 mg alone or in combination with ramelteon resulted in a reduction in development of delirium, time until delirium onset, and length of hospital stay. When assessed, suvorexant was well tolerated and adverse effects were no worse than placebo.CONCLUSION:
Based on the reviewed literature, suvorexant has shown positive outcomes in the prevention of delirium during an acute hospitalization. Larger trials comparing the efficacy of suvorexant to other sleep modulating options are necessary to further delineate its role for the prevention of delirium.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Azepinas
/
Triazoles
/
Cuidados Críticos
/
Delirio
/
Antagonistas de los Receptores de Orexina
/
Trastornos del Inicio y del Mantenimiento del Sueño
/
Tiempo de Internación
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Crit Care
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos