Bioassay Guided Isolation and Docking Studies of a Potential ß-Lactamase Inhibitor from <i>Clutia myricoides</i>.

Elfaky, Mahmoud A; El-Halawany, Ali M; Koshak, Abdulrahman E; Alshali, Khalid Z; El-Araby, Moustafa E; Khayat, Maan T; Abdallah, Hossam M

Bioassay Guided Isolation and Docking Studies of a Potential ß-Lactamase Inhibitor from Clutia myricoides.

Elfaky, Mahmoud A; El-Halawany, Ali M; Koshak, Abdulrahman E; Alshali, Khalid Z; El-Araby, Moustafa E; Khayat, Maan T; Abdallah, Hossam M.

Afiliación

Elfaky MA; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
El-Halawany AM; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Koshak AE; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Alshali KZ; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
El-Araby ME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Khayat MT; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Abdallah HM; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Molecules ; 25(11)2020 May 31.

Article en En | MEDLINE | ID: mdl-32486455

Asunto(s)

Magnoliopsida/química; Inhibidores de beta-Lactamasas/química; beta-Lactamasas/química; Antibacterianos/farmacología; Sitios de Unión; Bioensayo; Cefalosporinas/química; Cloroformo/química; Escherichia coli/efectos de los fármacos; Escherichia coli/enzimología; Furanos/química; Klebsiella pneumoniae/efectos de los fármacos; Klebsiella pneumoniae/enzimología; Espectroscopía de Resonancia Magnética; Pruebas de Sensibilidad Microbiana; Modelos Moleculares; Simulación del Acoplamiento Molecular; Unión Proteica; Inhibidores de beta-Lactamasas/farmacología

Palabras clave

Clutia myricoides; Klebsiella pneumoniae; antimicrobial resistance; bio-guided fractionation; molecular docking; ß-lactamase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Beta-Lactamasas / Magnoliopsida / Inhibidores de beta-Lactamasas Tipo de estudio: Prognostic_studies Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza

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