The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.
Anticancer Res
; 40(6): 3271-3276, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32487622
ABSTRACT
BACKGROUND/AIM:
This study aimed to determine the anxiolytic effect of a putative glyoxalase 1 inhibitor, piceatannol, as well as its antitumor activities on the stress-induced tumor growth of Lewis lung carcinoma. MATERIALS ANDMETHODS:
The anxiolytic activities of piceatannol (1-30 mg/kg) were assessed using the elevated plus maze (EPM) test. We also evaluated the pharmacological modulation of stress-induced tumor growth; the mice were treated with piceatannol (3 and 30 mg/kg) from the 10th day till the 19th day after administration of the LLC cells.RESULTS:
At the low dose (3 mg/kg), piceatannol significantly increased the time spent in the open arms of the EPM test when compared with the vehicle. At higher doses (30 mg/kg), it significantly suppressed the stress-induced enhancement of tumor growth.CONCLUSION:
A low dose of piceatannol exerts an anxiolytic effect, and high doses have an antitumor effect.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estilbenos
/
Ansiolíticos
/
Proteínas Tirosina Quinasas
/
Lactoilglutatión Liasa
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Anticancer Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón