Similar response rates and survival with PARP inhibitors for patients with solid tumors harboring somatic versus Germline BRCA mutations: a Meta-analysis and systematic review.

Mohyuddin, Ghulam Rehman; Aziz, Muhammad; Britt, Alec; Wade, Lee; Sun, Weijing; Baranda, Joaquina; Al-Rajabi, Raed; Saeed, Anwaar; Kasi, Anup

Mohyuddin, Ghulam Rehman; Aziz, Muhammad; Britt, Alec; Wade, Lee; Sun, Weijing; Baranda, Joaquina; Al-Rajabi, Raed; Saeed, Anwaar; Kasi, Anup.

Afiliación

Mohyuddin GR; University of Kansas, Kansas City, USA.
Aziz M; Department of Internal Medicine, University of Toledo, Toledo, USA.
Britt A; Department of Internal Medicine, University of Kansas, Kansas City, USA.
Wade L; University of Toledo Libraries, Toledo, USA.
Sun W; Division of Medical Oncology, University of Kansas Cancer Center, Kansas City, USA.
Baranda J; Division of Medical Oncology, University of Kansas Cancer Center, Kansas City, USA.
Al-Rajabi R; Division of Medical Oncology, University of Kansas Cancer Center, Kansas City, USA.
Saeed A; Division of Medical Oncology, University of Kansas Cancer Center, Kansas City, USA.
Kasi A; Division of Medical Oncology, University of Kansas Cancer Center, Kansas City, USA. akasi@kumc.edu.

BMC Cancer ; 20(1): 507, 2020 Jun 03.

Article en En | MEDLINE | ID: mdl-32493233

Asunto(s)

Proteína BRCA1/genética; Proteína BRCA2/genética; Resistencia a Antineoplásicos/genética; Neoplasias/tratamiento farmacológico; Inhibidores de Poli(ADP-Ribosa) Polimerasas/farmacología; Mutación de Línea Germinal; Humanos; Neoplasias/genética; Neoplasias/mortalidad; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Supervivencia sin Progresión

Palabras clave

BRCA; Germline; Meta-analysis; PARP inhibitors; Somatic

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a Antineoplásicos / Proteína BRCA1 / Proteína BRCA2 / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Neoplasias Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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