Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line.

Kumar, Nitin; Lal, Neetika; Nemaysh, Vishal; Luthra, Pratibha Mehta

Kumar, Nitin; Lal, Neetika; Nemaysh, Vishal; Luthra, Pratibha Mehta.

Afiliación

Kumar N; Neuropharmaceutical Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India. Electronic address: nitinvishnoi@gmail.com.
Lal N; Neuropharmaceutical Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
Nemaysh V; Neuropharmaceutical Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India.
Luthra PM; Neuropharmaceutical Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India. Electronic address: pmlsci2020@gmail.com.

Bioorg Chem ; 100: 103911, 2020 07.

Article en En | MEDLINE | ID: mdl-32502918

Asunto(s)

Antineoplásicos/química; Antineoplásicos/farmacología; Neoplasias Encefálicas/tratamiento farmacológico; Carbazoles/química; Carbazoles/farmacología; Glioma/tratamiento farmacológico; Antineoplásicos/síntesis química; Neoplasias Encefálicas/metabolismo; Carbazoles/síntesis química; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; ADN/metabolismo; Diseño de Fármacos; Glioma/metabolismo; Humanos; Simulación del Acoplamiento Molecular

Palabras clave

BCNU (Carmustine-Bis-Chloro ethyl-NitrosoUrea); CCNU(Lomustine-CyclohexylChloroethylNitrosoUrea); CD (Circular Dichroism); CT-DNA (Calf thymus-deoxyribonucleic acid); Compound 34 (bis((6-methoxy-1,4-dimethyl-9H-carbazol-3-yl)methyl) amine); EtBr (Ethidium Bromide); GBM (Glioblastoma); Half maximum inhibitory concentration (IC(50)); Human glioma U87 MG cell line; MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide); TMZ (Temozolomide)

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carbazoles / Glioma / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google