Your browser doesn't support javascript.
loading
SAP interacts with CD28 to inhibit PD-1 signaling in T lymphocytes.
Sandigursky, Sabina; Philips, Mark R; Mor, Adam.
Afiliación
  • Sandigursky S; Department of Medicine, NYU School of Medicine, New York, NY 10016, USA.
  • Philips MR; Department of Medicine, NYU School of Medicine, New York, NY 10016, USA.
  • Mor A; Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: am5121@cumc.columbia.edu.
Clin Immunol ; 217: 108485, 2020 08.
Article en En | MEDLINE | ID: mdl-32504780
T cell co-stimulation is important for the maintenance of immunologic tolerance. Co-inhibitory receptors including programmed cell death-1 (PD-1) confer peripheral tolerance to prevent autoimmunity. SAP (SH2D1A) is an adaptor molecule that is important in T cell signaling and has been shown to interact with signaling lymphocytic activation molecule (SLAM) family receptors also in the context of self-tolerance. We recently reported that SAP interferes with PD-1 function. In the current study, we investigated the levels of SAP and PD-1 in patients with rheumatoid arthritis (RA) to further understand what role they play in disease activity. We observed increased SAP levels in lymphocytes of RA patients and found that PD-1 levels correlated positively with RA disease activity. Additionally, we found that SAP interacts with CD28 to inhibit T cell signaling in vitro. This work demonstrates a putative molecular mechanism for SAP mediated PD-1 inhibition.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Linfocitos T / Antígenos CD28 / Receptor de Muerte Celular Programada 1 / Proteína Asociada a la Molécula de Señalización de la Activación Linfocitaria Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Linfocitos T / Antígenos CD28 / Receptor de Muerte Celular Programada 1 / Proteína Asociada a la Molécula de Señalización de la Activación Linfocitaria Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos