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Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967.
Chen, Jih-Jung; Wang, Shih-Wei; Chiang, Yin-Ru; Pang, Ka-Lai; Kuo, Yueh-Hsiung; Shih, Tsai-Yen; Lee, Tzong-Huei.
Afiliación
  • Chen JJ; Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan.
  • Wang SW; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
  • Chiang YR; Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan.
  • Pang KL; Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
  • Kuo YH; Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan.
  • Shih TY; Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan.
  • Lee TH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40447, Taiwan.
Mar Drugs ; 18(6)2020 Jun 06.
Article en En | MEDLINE | ID: mdl-32517237
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid-state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A-G (1-7), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7-7.3 µM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergillus / Proliferación Celular / Policétidos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergillus / Proliferación Celular / Policétidos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza