Reconstitution Time for Highly Concentrated Lyophilized Proteins: Role of Formulation and Protein.

Kulkarni, Shreya S; Patel, Sajal M; Bogner, Robin H

Kulkarni, Shreya S; Patel, Sajal M; Bogner, Robin H.

Afiliación

Kulkarni SS; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269, USA.
Patel SM; Dosage Form Design & Development, Biopharmaceutical Development, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD 20878, USA.
Bogner RH; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269, USA; Institute of Materials Science, University of Connecticut, 97 North Eagleville Road, Storrs, CT 06269, USA. Electronic address: robin.bogner@uconn.edu.

J Pharm Sci ; 109(10): 2975-2985, 2020 10.

Article en En | MEDLINE | ID: mdl-32534031

Asunto(s)

Excipientes; Proteínas; Liofilización; Porosidad; Humectabilidad

Palabras clave

Amorphous; Contact angle; Crushing strength; Crystallinity; Freeze drying; High concentration; Lyophilization; Protein formulation; Reconstitution/dissolution; Viscosity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Excipientes Idioma: En Revista: J Pharm Sci Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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