Impaired Visual Habituation in Idiopathic Generalized Epilepsy with Photosensitivity Patients.
Noro Psikiyatr Ars
; 57(2): 108-112, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-32550775
ABSTRACT
INTRODUCTION:
In this study, our goal was to analyze further the cortical excitability levels in idiopathic generalized epilepsy (IGE) patients with and without photosensitivity.METHODS:
Forty-two patients (16 men and 26 women; mean age 30±8 years; range 18-43 years) with IGE and thirty healthy age-matched control subjects (15 men and 15 women; mean age 35±3 years; range 20-45 years) were enrolled for the investigation. We investigated the following two groups 18 subjects with IGE with photosensitivity (IGE+PS), and 24 patients with IGE without photosensitivity (IGE-PS). Pattern reversal and potential inter-peak amplitudes, N75-P100 and P100-N145, as well as the corresponding latencies (N75, P100, and N145) for one hundred responses were measured 6 times. A linear regression slope was used for N75-P100 and P100-N145.RESULTS:
Statistical analysis showed difference between groups where the IGE+PS had reduced N75-P100 compared to IGE-PS and controls. In IGE+PS group, the amplitude of N75-P100 was drastically reduced receiving antiepileptic therapy compared to those not receiving any anti-epileptic treatment (p=0.035).CONCLUSION:
These results show that the IGE+PS group has a different photoparoxysmal response phenotype driven by an unknown and distinct molecular mechanism. Pre-activation cortical excitability may be increased in IGE+PS patients compared to the IGE-PS or in healthy group. PR-VEP habituation may project the pathophysiological mechanisms underlying photosensitivity and it may be potential biomarker in patients with IGE+PS.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Noro Psikiyatr Ars
Año:
2020
Tipo del documento:
Article
País de afiliación:
Turquía