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A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø, Morten T; Reschke, Cristina R; Morris, Gareth; Connolly, Niamh M C; Su, Junyi; Yan, Yan; Engel, Tobias; Jimenez-Mateos, Eva M; Harder, Lea M; Pultz, Dennis; Haunsberger, Stefan J; Pal, Ajay; Heller, Janosch P; Campbell, Aoife; Langa, Elena; Brennan, Gary P; Conboy, Karen; Richardson, Amy; Norwood, Braxton A; Costard, Lara S; Neubert, Valentin; Del Gallo, Federico; Salvetti, Beatrice; Vangoor, Vamshidhar R; Sanz-Rodriguez, Amaya; Muilu, Juha; Fabene, Paolo F; Pasterkamp, R Jeroen; Prehn, Jochen H M; Schorge, Stephanie; Andersen, Jens S; Rosenow, Felix; Bauer, Sebastian; Kjems, Jørgen; Henshall, David C.
Afiliación
  • Venø MT; Interdisciplinary Nanoscience Centre, Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark.
  • Reschke CR; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Morris G; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Connolly NMC; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Su J; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Yan Y; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.
  • Engel T; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Jimenez-Mateos EM; Interdisciplinary Nanoscience Centre, Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark.
  • Harder LM; Interdisciplinary Nanoscience Centre, Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark.
  • Pultz D; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Haunsberger SJ; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Pal A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Heller JP; Center for Experimental Bioinformatics, University of Southern Denmark, DK-5230 Odense M, Denmark.
  • Campbell A; Center for Experimental Bioinformatics, University of Southern Denmark, DK-5230 Odense M, Denmark.
  • Langa E; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Brennan GP; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Conboy K; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Richardson A; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Norwood BA; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.
  • Costard LS; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Neubert V; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Del Gallo F; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Salvetti B; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Vangoor VR; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Sanz-Rodriguez A; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Muilu J; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Fabene PF; FutureNeuro, The Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, Dublin, D02 YN77, Ireland.
  • Pasterkamp RJ; Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom.
  • Prehn JHM; Department of Neuroscience, Expesicor Inc, Kalispell, MT 59901.
  • Schorge S; Diagnostics Development, FYR Diagnostics, Missoula, MT 59801.
  • Andersen JS; Epilepsy Center, Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.
  • Rosenow F; Epilepsy Center Frankfurt Rhine-Main, Neurocenter, University Hospital Frankfurt and Center for Personalized Translational Epilepsy Research, Goethe University Frankfurt, 60528, Frankfurt, Germany.
  • Bauer S; Epilepsy Center, Department of Neurology, Philipps University Marburg, 35043, Marburg, Germany.
  • Kjems J; Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Rostock, 18051, Germany.
  • Henshall DC; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 8 - 37134, Verona, Italy.
Proc Natl Acad Sci U S A ; 117(27): 15977-15988, 2020 07 07.
Article en En | MEDLINE | ID: mdl-32581127
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Oligonucleótidos Antisentido / MicroARNs / Epilepsia del Lóbulo Temporal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Convulsiones / Oligonucleótidos Antisentido / MicroARNs / Epilepsia del Lóbulo Temporal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article País de afiliación: Dinamarca