Inhibition of cellular phosphatidylinositol turnover by psi-tectorigenin.
FEBS Lett
; 230(1-2): 43-6, 1988 Mar 28.
Article
en En
| MEDLINE
| ID: mdl-3258253
ABSTRACT
Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 microgram/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfatidilinositoles
/
Flavonoides
/
Actinomycetales
/
Isoflavonas
Idioma:
En
Revista:
FEBS Lett
Año:
1988
Tipo del documento:
Article
País de afiliación:
Japón