Models of Gastroenteropancreatic Neuroendocrine Neoplasms: Current Status and Future Directions.
Neuroendocrinology
; 111(3): 217-236, 2021.
Article
en En
| MEDLINE
| ID: mdl-32615560
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a rare, heterogeneous group of tumors that originate from the endocrine system of the gastrointestinal tract and pancreas. GEP-NENs are subdivided according to their differentiation into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Since GEP-NENs represent rare diseases, only limited data from large prospective, randomized clinical trials are available, and recommendations for treatment of GEP-NEN are in part based on data from retrospective analyses or case series. In this context, tractable disease models that reflect the situation in humans and that allow to recapitulate the different clinical aspects and disease stages of GEP-NET or GEP-NEC are urgently needed. In this review, we highlight available data on mouse models for GEP-NEN. We discuss how these models reflect tumor biology of human disease and whether these models could serve as a tool for understanding the pathogenesis of GEP-NEN and for disease modeling and pharmacosensitivity assays, facilitating prediction of treatment response in patients. In addition, open issues applicable for future developments will be discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Neoplasias Gástricas
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Tumores Neuroendocrinos
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Línea Celular Tumoral
/
Modelos Animales de Enfermedad
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Neoplasias Intestinales
Tipo de estudio:
Clinical_trials
/
Guideline
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuroendocrinology
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Suiza