GABA-B Receptor Encephalitis Triggered by Enterovirus Encephalitis in a Patient With Small Cell Lung Cancer: A Case Report.
Neurologist
; 25(4): 106-108, 2020 Jul.
Article
en En
| MEDLINE
| ID: mdl-32618841
INTRODUCTION: Encephalitis with gamma-aminobutyric acid (GABA)-B receptor antibodies (GABA-B receptor encephalitis) is known to have underlying neoplastic condition in half of the cases; however, there could be an additional event that could work as a trigger factor. Here, we report a patient with GABA-B receptor encephalitis associated with small cell lung cancer, which was probably triggered by enterovirus encephalitis. CASE REPORT: A 53-year-old man was admitted for a seizure, following fever and headache for 3 days. Status epilepticus developed on the following day. Brain magnetic resonance imaging (MRI) was normal. Cerebrospinal fluid (CSF) study revealed lymphocyte-dominant pleocytosis, and enterovirus was detected by polymerase chain reaction test in CSF later. The patient recovered after 2 weeks of treatment. Another 2 weeks later, he showed confusion and seizure without fever. Follow-up CSF study revealed no abnormalities; however, MRI showed a lesion with vasogenic edema on the right posterior hippocampus. GABA-B receptor antibodies were found in the serum and CSF. The chest computed tomography revealed a mass on his right upper lung, which was confirmed as a small cell lung cancer. GABA-B receptor encephalitis associated with small cell lung cancer was diagnosed, and intravenous immunoglobulin and methylprednisolone were infused. Following treatment, seizures and delirium stopped, and the patient recovered to a near normal state. Follow-up MRI performed 2 months later showed that the hippocampal lesion had disappeared. CONCLUSION: In cases of infectious encephalitis with an atypical recurrent course, the possibility of newly onset autoimmune encephalitis should be considered.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores de GABA-B
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Encefalitis Viral
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Síndromes Paraneoplásicos del Sistema Nervioso
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Infecciones por Enterovirus
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Carcinoma Pulmonar de Células Pequeñas
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Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurologist
Asunto de la revista:
NEUROLOGIA
Año:
2020
Tipo del documento:
Article
Pais de publicación:
Estados Unidos