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The influence of biomechanical stability on bone healing and fracture-related infection: the legacy of Stephan Perren.
Foster, Andrew L; Moriarty, T Fintan; Zalavras, Charalampos; Morgenstern, Mario; Jaiprakash, Anjali; Crawford, Ross; Burch, Marc-Antoine; Boot, Willemijn; Tetsworth, Kevin; Miclau, Theodore; Ochsner, Peter; Schuetz, Michael A; Richards, R Geoff; Metsemakers, Willem-Jan.
Afiliación
  • Foster AL; AO Research Institute Davos, Davos, Switzerland; Queensland University of Technology, Brisbane, Australia; Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.
  • Moriarty TF; AO Research Institute Davos, Davos, Switzerland.
  • Zalavras C; Department of Orthopaedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  • Morgenstern M; Department of Orthopedic and Trauma Surgery, Basel, Switzerland.
  • Jaiprakash A; Queensland University of Technology, Brisbane, Australia.
  • Crawford R; Queensland University of Technology, Brisbane, Australia.
  • Burch MA; AO Research Institute Davos, Davos, Switzerland; Department of Orthopedic and Trauma Surgery, Basel, Switzerland.
  • Boot W; AO Research Institute Davos, Davos, Switzerland.
  • Tetsworth K; Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.
  • Miclau T; Department of Orthopaedic Surgery, University of California, San Francisco, Orthopaedic Trauma Institute, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
  • Ochsner P; Medical University Basel, Switzerland.
  • Schuetz MA; AO Research Institute Davos, Davos, Switzerland; Department of Orthopaedic Surgery, Royal Brisbane and Women's Hospital, Australia; Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Australia.
  • Richards RG; AO Research Institute Davos, Davos, Switzerland.
  • Metsemakers WJ; Department of Trauma Surgery, University Hospital Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Belgium. Electronic address: willem-jan.metsemakers@uzleuven.be.
Injury ; 52(1): 43-52, 2021 Jan.
Article en En | MEDLINE | ID: mdl-32620328
ABSTRACT
Bone healing is a complicated process of tissue regeneration that is influenced by multiple biological and biomechanical processes. In a minority of cases, these physiological processes are complicated by issues such as nonunion and/or fracture-related infection (FRI). Based on a select few in vivo experimental animal studies, construct stability is considered an important factor influencing both prevention and treatment of FRI. Stephan Perren played a pivotal role in the evolution of our current understanding of the critical relationship between biomechanics, fracture healing and infection. Furthermore, his concept of strain theory and the process of fracture healing is familiar to several generations of surgeons and has influenced implant development and design for the past 50 years. In this review we describe the role of biomechanical stability on fracture healing, and provide a detailed analysis of the preclinical studies addressing this in the context of FRI. Furthermore, we demonstrate how Perren's concepts of stability are still applied to current surgical techniques to aid in the prevention and treatment of FRI. Finally, we highlight the key knowledge gaps in the underlying basic research literature that need to be addressed as we continue to optimize patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fracturas Óseas Límite: Animals / Humans Idioma: En Revista: Injury Año: 2021 Tipo del documento: Article País de afiliación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fracturas Óseas Límite: Animals / Humans Idioma: En Revista: Injury Año: 2021 Tipo del documento: Article País de afiliación: Australia