Cell therapy for prenatal repair of myelomeningocele: A systematic review.
Curr Res Transl Med
; 68(4): 183-189, 2020 11.
Article
en En
| MEDLINE
| ID: mdl-32624428
ABSTRACT
Myelomeningocele (MMC) is a spinal cord congenital defect that leads to paraplegia, bladder incontinence and bowel dysfunction. A randomized human trial demonstrated that in utero surgical repair of the MMC defect improves lower limb motor function. However, functional recovery remains incomplete. Stem cell therapy has recently generated great interest in the field of prenatal repair of MMC. In this systematic review we attempt to provide an overview of the current application of stem cells in different animal models of MMC. Publications were retrieved from PubMed and Cochrane Library databases. This process yielded twenty-two studies for inclusion in this review, experimenting five different types of stem cells human embryonic stem cells, neural stem cells, induced pluripotent stem cells, human amniotic fluid stem cells, and mesenchymal stem cells (MSCs). Rodents and ovine were the two major species used for animal model studies. The source, the aims, and the main results were analyzed. Stem cell therapy appears to be a promising candidate for prenatal repair of MMC, especially MSCs. Further explorations in ovine and rodent models, reporting clinical and functional results, are necessary before an application in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre
/
Células Madre Mesenquimatosas
/
Tratamiento Basado en Trasplante de Células y Tejidos
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Res Transl Med
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia