Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy.
Cancer Res
; 80(21): 4593-4600, 2020 11 01.
Article
en En
| MEDLINE
| ID: mdl-32651257
ABSTRACT
Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-dependent repair and classical nonhomologous end-joining. Recent studies have identified a third pathway, microhomology-mediated end-joining (MMEJ). MMEJ has similarities to homology-dependent repair, in that repair is initiated with end resection, leading to single-stranded 3' ends, which require microhomology upstream and downstream of the DSB. Importantly, the MMEJ pathway is commonly upregulated in cancers, especially in homologous recombination-deficient cancers, which display a distinctive mutational signature. Here, we review the molecular process of MMEJ as well as new targets and approaches exploiting the MMEJ pathway in cancer therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Roturas del ADN de Doble Cadena
/
Reparación del ADN por Unión de Extremidades
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Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Año:
2020
Tipo del documento:
Article