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Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.
Sharkey, Lisa M; Sandoval-Pistorius, Stephanie S; Moore, Shannon J; Gerson, Julia E; Komlo, Robert; Fischer, Svetlana; Negron-Rios, Keyshla Y; Crowley, Emily V; Padron, Francisco; Patel, Ronak; Murphy, Geoffrey G; Paulson, Henry L.
Afiliación
  • Sharkey LM; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America. Electronic address: lisams@med.umich.edu.
  • Sandoval-Pistorius SS; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, United States of America.
  • Moore SJ; Michigan Neuroscience Institute and Department of Physiology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Gerson JE; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Komlo R; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Fischer S; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Negron-Rios KY; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Crowley EV; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Padron F; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Patel R; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Murphy GG; Michigan Neuroscience Institute and Department of Physiology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America.
  • Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, United States of America. Electronic address: henryp@med.umich.edu.
Neurobiol Dis ; 143: 105016, 2020 09.
Article en En | MEDLINE | ID: mdl-32653673
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas Adaptadoras Transductoras de Señales / Modelos Animales de Enfermedad / Proteínas Relacionadas con la Autofagia / Degeneración Nerviosa / Neuronas Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Proteínas Adaptadoras Transductoras de Señales / Modelos Animales de Enfermedad / Proteínas Relacionadas con la Autofagia / Degeneración Nerviosa / Neuronas Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos