The Bacterial Ro60 Protein and Its Noncoding Y RNA Regulators.
Annu Rev Microbiol
; 74: 387-407, 2020 09 08.
Article
en En
| MEDLINE
| ID: mdl-32660384
ABSTRACT
Ro60 ribonucleoproteins (RNPs), composed of the ring-shaped Ro 60-kDa (Ro60) protein and noncoding RNAs called Y RNAs, are present in all three domains of life. Ro60 was first described as an autoantigen in patients with rheumatic disease, and Ro60 orthologs have been identified in 3% to 5% of bacterial genomes, spanning the majority of phyla. Their functions have been characterized primarily in Deinococcus radiodurans, the first sequenced bacterium with a recognizable ortholog. In D. radiodurans, the Ro60 ortholog enhances the ability of 3'-to-5' exoribonucleases to degrade structured RNA during several forms of environmental stress. Y RNAs are regulators that inhibit or allow the interactions of Ro60 with other proteins and RNAs. Studies of Ro60 RNPs in other bacteria hint at additional functions, since the most conserved Y RNA contains a domain that is a close tRNA mimic and Ro60 RNPs are often encoded adjacent to components of RNA repair systems.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribonucleoproteínas
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Proteínas Bacterianas
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ARN Bacteriano
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Regulación Bacteriana de la Expresión Génica
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ARN no Traducido
Idioma:
En
Revista:
Annu Rev Microbiol
Año:
2020
Tipo del documento:
Article