The role of the I<sub>T</sub>-state in D76N ß<sub>2</sub>-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

Smith, Hugh I; Guthertz, Nicolas; Cawood, Emma E; Maya-Martinez, Roberto; Breeze, Alexander L; Radford, Sheena E

The role of the I_T-state in D76N ß₂-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

Smith, Hugh I; Guthertz, Nicolas; Cawood, Emma E; Maya-Martinez, Roberto; Breeze, Alexander L; Radford, Sheena E.

Afiliación

Smith HI; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Guthertz N; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Cawood EE; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Maya-Martinez R; School of Chemistry, University of Leeds, Leeds, United Kingdom.
Breeze AL; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Radford SE; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.

J Biol Chem ; 295(35): 12474-12484, 2020 08 28.

Article en En | MEDLINE | ID: mdl-32661194

Asunto(s)

Amiloide/química; Simulación de Dinámica Molecular; Agregado de Proteínas; Microglobulina beta-2/química; Sustitución de Aminoácidos; Amiloide/genética; Cristalografía por Rayos X; Humanos; Mutación Missense; Microglobulina beta-2/genética

Palabras clave

CD; D76N; NMR; aggregation; amyloid; biophysics; folding intermediate; protein aggregation; protein folding; real-time folding; ß2-microglobulin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglobulina beta-2 / Simulación de Dinámica Molecular / Agregado de Proteínas / Amiloide Límite: Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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