Noninvasive Cellular Oxygenation Measurement During Graded Hypoxia Using Visible-Near-Infrared Spectroscopy.
Appl Spectrosc
; 74(10): 1263-1273, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-32662282
ABSTRACT
In critically ill patients, direct knowledge of intracellular pO2 would allow for identification of cellular hypoxia, which when prolonged leads to organ failure. We have developed a visible-near-infrared optical system that noninvasively measures myoglobin saturation, which is directly related to intracellular pO2, from the surface of the skin. We used an animal model of graded hypoxia from low levels of inspired oxygen (n = 5) and verified that low intracellular pO2 is correlated with high steady-state serum lactate values. In addition, the pO2 gradient between arterial blood and inside muscle cells was 83 mm Hg at 21% O2, but fell to 24 mm Hg at 8% O2. Continuous myoglobin saturation measurement in skeletal muscle displayed the same trends as cerebral oxygenation with no lag in changes over time, demonstrating its relevance as a measure of systemic oxygenation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxihemoglobinas
/
Hipoxia de la Célula
/
Músculo Esquelético
/
Espectroscopía Infrarroja Corta
/
Mioglobina
Límite:
Animals
Idioma:
En
Revista:
Appl Spectrosc
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos