The associations between neutrophil-to-lymphocyte ratio and the Chinese Visceral Adiposity Index, and carotid atherosclerosis and atherosclerotic cardiovascular disease risk.
Exp Gerontol
; 139: 111019, 2020 10 01.
Article
en En
| MEDLINE
| ID: mdl-32663589
ABSTRACT
BACKGROUND:
Inflammation and obesity are the main risk factors for the development of carotid atherosclerosis and atherosclerotic cardiovascular disease (ASCVD). The neutrophil-to-lymphocyte ratio (NLR) is a recently developed indicator of inflammation that can be easily calculated from blood cell counts. The Chinese Visceral Adiposity Index (CVAI) was used to assess visceral obesity in the Chinese population.AIMS:
To explore the associations between both NLR and CVAI, and carotid atherosclerosis and ASCVD risk in elderly Chinese.METHODS:
A total of 4437 participants aged ≥55 years and with no history of cardiovascular disease, were enrolled in this retrospective study. Anthropometric measurements, laboratory results, and carotid ultrasonography results were extracted from a database. We used established formulas to calculate NLR and CVAI, and the Pooled Cohort Equations to generate the 10-year ASCVD risk score. Participants were divided into two groups according to their 10-year ASCVD scores <7.5% and ≥7.5%.RESULTS:
NLR and CVAI were significantly higher in patients with carotid atherosclerosis. Regression analysis showed that NLR (OR 1.23, 95% CI 1.05-1.43, p = 0.01) and CVAI (OR 1.39, 95% CI 1.21-1.61, p = 0.001) were independent risk factors for carotid atherosclerosis. A combination of NLR and CVAI improved the goodness-of-fit (p < 0.001) and discriminability of the model (p = 0.0013). NLR, CVAI and carotid plaques showed positive associations with the 10-year ASCVD risk score (all p < 0.001).CONCLUSIONS:
NLR and CVAI are positively associated with the prevalence of carotid atherosclerosis and high risk of ASCVD in elderly adults and could be useful in the identification of a high risk of atherosclerosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Enfermedades de las Arterias Carótidas
/
Aterosclerosis
/
Obesidad Abdominal
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Exp Gerontol
Año:
2020
Tipo del documento:
Article
País de afiliación:
China