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Clinical and biological impact of the exposome on the skin.
Passeron, T; Krutmann, J; Andersen, M L; Katta, R; Zouboulis, C C.
Afiliación
  • Passeron T; Côte d'Azur University, Department of Dermatology, University Hospital Centre Nice, Nice, France.
  • Krutmann J; Côte d'Azur University, INSERM U1065, C3M, Nice, France.
  • Andersen ML; IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
  • Katta R; Medical faculty, Heinrich-Heine-University, Düsseldorf, Germany.
  • Zouboulis CC; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)/Escola Paulista de Medicina, São Paulo, Brazil.
J Eur Acad Dermatol Venereol ; 34 Suppl 4: 4-25, 2020 Jul.
Article en En | MEDLINE | ID: mdl-32677068
The skin exposome is defined as the totality of environmental exposures over the life course that can induce or modify various skin conditions. Here, we review the impact on the skin of solar exposure, air pollution, hormones, nutrition and psychological factors. Photoageing, photocarcinogenesis and pigmentary changes are well-established consequences of chronic exposure of the skin to solar radiation. Exposure to traffic-related air pollution contributes to skin ageing. Particulate matter and nitrogen dioxide cause skin pigmentation/lentigines, while ozone causes wrinkles and has an impact on atopic eczema. Human skin is a major target of hormones, and they exhibit a wide range of biological activities on the skin. Hormones decline with advancing age influencing skin ageing. Nutrition has an impact on numerous biochemical processes, including oxidation, inflammation and glycation, which may result in clinical effects, including modification of the course of skin ageing and photoageing. Stress and lack of sleep are known to contribute to a pro-inflammatory state, which, in turn, affects the integrity of extracellular matrix proteins, in particular collagen. Hormone dysregulation, malnutrition and stress may contribute to inflammatory skin disorders, such as atopic dermatitis, psoriasis, acne and rosacea.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminación del Aire / Exposoma Límite: Humans Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminación del Aire / Exposoma Límite: Humans Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido