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Global distribution of epidemic-related Shiga toxin 2 encoding phages among enteroaggregative Escherichia coli.
Kimata, Keiko; Lee, Kenichi; Watahiki, Masanori; Isobe, Junko; Ohnishi, Makoto; Iyoda, Sunao.
Afiliación
  • Kimata K; Department of Bacteriology, Toyama Institute of Health, Toyama, 9390363, Japan.
  • Lee K; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 1628640, Japan. leek@niid.go.jp.
  • Watahiki M; Department of Bacteriology, Toyama Institute of Health, Toyama, 9390363, Japan.
  • Isobe J; Department of Bacteriology, Toyama Institute of Health, Toyama, 9390363, Japan.
  • Ohnishi M; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 1628640, Japan.
  • Iyoda S; Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 1628640, Japan.
Sci Rep ; 10(1): 11738, 2020 07 16.
Article en En | MEDLINE | ID: mdl-32678145
Since the Shiga toxin-producing enteroaggregative Escherichia coli (Stx-EAEC) O104:H4 strain caused a massive outbreak across Europe in 2011, the importance of Stx-EAEC has attracted attention from a public health perspective. Two Stx-EAEC O86 isolates were obtained from patients with severe symptoms in Japan in 1999 and 2015. To characterize the phylogeny and pathogenic potential of these Stx-EAEC O86 isolates, whole-genome sequence analyses were performed by short-and long-read sequencing. Among genetically diverse E. coli O86, the Stx-EAEC O86 isolates were clustered with the EAEC O86:H27 ST3570 subgroup. Strikingly, there were only two loci with single nucleotide polymorphisms (SNPs) between the Stx2a phage of a Japanese O86:H27 isolate and that of the European epidemic-related Stx-EAEC O104:H4 isolate. These results provide evidence of global distribution of epidemic-related Stx2a phages among various lineages of E. coli with few mutations.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxina Shiga II / Infecciones por Escherichia coli / Escherichia coli Enteropatógena / Escherichia coli Shiga-Toxigénica Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Toxina Shiga II / Infecciones por Escherichia coli / Escherichia coli Enteropatógena / Escherichia coli Shiga-Toxigénica Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido