Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines.

Dinger, Thiemo F; Chen, Oleg; Dittfeld, Claudia; Hetze, Lydia; Hüther, Melanie; Wondrak, Marit; Löck, Steffen; Eicheler, Wolfgang; Breier, Georg; Kunz-Schughart, Leoni A

Dinger, Thiemo F; Chen, Oleg; Dittfeld, Claudia; Hetze, Lydia; Hüther, Melanie; Wondrak, Marit; Löck, Steffen; Eicheler, Wolfgang; Breier, Georg; Kunz-Schughart, Leoni A.

Afiliación

Dinger TF; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Chen O; Department of Neurosurgery, University Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Germany.
Dittfeld C; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Hetze L; Department of Cell Signaling, Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine.
Hüther M; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Wondrak M; Department of Cardiac Surgery, Herzzentrum Dresden, Faculty of Medicine Carl Gustav Carus, TU Dresden, Germany.
Löck S; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Eicheler W; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Breier G; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.
Kunz-Schughart LA; OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, and Helmholtz-Zentrum Dresden-Rossendorf, Germany.

Theranostics ; 10(17): 7599-7621, 2020.

Article en En | MEDLINE | ID: mdl-32685007

Asunto(s)

Carcinogénesis/patología; Neoplasias Colorrectales/patología; Receptores de Hialuranos/metabolismo; Células Madre Neoplásicas/patología; Microambiente Tumoral; Antígeno AC133/metabolismo; Animales; Biomarcadores de Tumor/metabolismo; Fibroblastos Asociados al Cáncer/patología; Línea Celular Tumoral; Plasticidad de la Célula; Separación Celular; Femenino; Citometría de Flujo; Células Endoteliales de la Vena Umbilical Humana; Humanos; Ratones; Isoformas de Proteínas/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

CD44/CD44v8-10; colorectal cancer; fibroblasts; limiting dilution engraftment; microenvironment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Colorrectales / Receptores de Hialuranos / Microambiente Tumoral / Carcinogénesis Límite: Animals / Female / Humans Idioma: En Revista: Theranostics Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Australia

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