Colonization with Staphylococcus aureus in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization.
Contact Dermatitis
; 83(6): 442-449, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-32720317
ABSTRACT
BACKGROUND:
While Staphylococcus aureus (S. aureus) colonization has been thoroughly studied in atopic dermatitis (AD), where S. aureus is related to flares and considered a trigger factor, S. aureus colonization in hand eczema (HE) has only been sparsely studied.OBJECTIVES:
To examine the 1-week prevalence of S. aureus colonization in HE patients, and its association with severity, HE subtype, AD, and nasal S. aureus colonization compared with healthy controls.METHODS:
In a case-control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non-lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of S. aureus on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity.RESULTS:
Twenty-seven HE patients (54%) were colonized with S. aureus on the hand compared to one control (2%) (P < .01). Nasal S. aureus colonization was found in 72% of patients and 22% of controls (P < .01). For patients, S. aureus colonization on the hands was associated with an atopic HE subtype and HE severity (P = .01 and P < .01, respectively).CONCLUSIONS:
Both hand and nasal S. aureus colonization were highly prevalent among HE-patients and may have an impact on the persistence of HE.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
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Infecciones Cutáneas Estafilocócicas
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Dermatitis Atópica
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Dermatosis de la Mano
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Mucosa Nasal
Tipo de estudio:
Observational_studies
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Prevalence_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Contact Dermatitis
Año:
2020
Tipo del documento:
Article
País de afiliación:
Dinamarca