Two-weekly docetaxel in treatment of advanced breast cancer: A preliminary study.
Med J Malaysia
; 75(4): 338-341, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32723991
ABSTRACT
OBJECTIVE:
Three-weekly docetaxel causes a high rate of febrile neutropenia, especially in the Asian population. Two-weekly docetaxel has been shown to reduce rate of febrile neutropenia in castrate-resistant prostate cancer patients. We conducted a preliminary study to investigate the safety of two-weekly docetaxel in advanced breast cancer patients.METHODS:
We recruited 10 patients with advanced breast cancer with ECOG (Eastern Cooperative Oncology Group) performance status score of zero to two, who needed chemotherapy in the first or second-line setting to receive two-weekly docetaxel for 8 cycles. The primary endpoint was safety and secondary endpoints were response rate and progression free survival.RESULTS:
The most reported adverse events were haematological (anaemia 100% and neutropenia 90%). The febrile neutropenia rate was 10%. The overall response rate was 20%. The median progression free survival was 5.0 months.CONCLUSION:
Two-weekly docetaxel may be a reasonable alternative treatment regimen for patients with advanced breast cancer in the first or second-line setting. This regimen is yet to be compared with standard 3-weekly schedule in a phase 3 randomised clinical trial.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Docetaxel
/
Antineoplásicos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
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Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Med J Malaysia
Año:
2020
Tipo del documento:
Article
País de afiliación:
Malasia