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Perspectives on ENCODE.
Snyder, Michael P; Gingeras, Thomas R; Moore, Jill E; Weng, Zhiping; Gerstein, Mark B; Ren, Bing; Hardison, Ross C; Stamatoyannopoulos, John A; Graveley, Brenton R; Feingold, Elise A; Pazin, Michael J; Pagan, Michael; Gilchrist, Daniel A; Hitz, Benjamin C; Cherry, J Michael; Bernstein, Bradley E; Mendenhall, Eric M; Zerbino, Daniel R; Frankish, Adam; Flicek, Paul; Myers, Richard M.
Afiliación
  • Snyder MP; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA. mpsnyder@stanford.edu.
  • Gingeras TR; Cardiovascular Institute, Stanford School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.
  • Moore JE; Functional Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Weng Z; University of Massachusetts Medical School, Program in Bioinformatics and Integrative Biology, Worcester, MA, USA.
  • Gerstein MB; University of Massachusetts Medical School, Program in Bioinformatics and Integrative Biology, Worcester, MA, USA.
  • Ren B; Department of Thoracic Surgery, Clinical Translational Research Center, Shanghai Pulmonary Hospital, The School of Life Sciences and Technology, Tongji University, Shanghai, China.
  • Hardison RC; Bioinformatics Program, Boston University, Boston, MA, USA.
  • Stamatoyannopoulos JA; Yale University, New Haven, CT, USA.
  • Graveley BR; Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA, USA.
  • Feingold EA; Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.
  • Pazin MJ; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.
  • Pagan M; Altius Institute for Biomedical Sciences, Seattle, WA, USA.
  • Gilchrist DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.
  • Hitz BC; Department of Medicine, University of Washington, Seattle, WA, USA.
  • Cherry JM; Department of Genetics and Genome Sciences, Institute for Systems Genomics, UConn Health, Farmington, CT, USA.
  • Bernstein BE; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Mendenhall EM; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Zerbino DR; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Frankish A; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • Flicek P; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA.
  • Myers RM; Department of Genetics, School of Medicine, Stanford University, Palo Alto, CA, USA.
Nature ; 583(7818): 693-698, 2020 07.
Article en En | MEDLINE | ID: mdl-32728248
ABSTRACT
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma / Genómica / Bases de Datos Genéticas / Anotación de Secuencia Molecular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nature Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma / Genómica / Bases de Datos Genéticas / Anotación de Secuencia Molecular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nature Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos