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Design, synthesis and high antitumor potential of new unsymmetrical bisacridine derivatives towards human solid tumors, specifically pancreatic cancers and their unique ability to stabilize DNA G-quadruplexes.
Paluszkiewicz, Ewa; Horowska, Barbara; Borowa-Mazgaj, Barbara; Peszynska-Sularz, Grazyna; Paradziej-Lukowicz, Jolanta; Augustin, Ewa; Konopa, Jerzy; Mazerska, Zofia.
Afiliación
  • Paluszkiewicz E; Chemical Faculty, Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Narutowicza 11/12 Str., 80-233, Gdansk, Poland.
  • Horowska B; Chemical Faculty, Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Narutowicza 11/12 Str., 80-233, Gdansk, Poland.
  • Borowa-Mazgaj B; FDA National Center for Toxicological Research, Biochemical Toxicology, Jefferson, United States.
  • Peszynska-Sularz G; Tri-City Central Animal Laboratory - Research and Service Centre, Medical University of Gdansk, Debinki 1 Str., 80-211, Gdansk, Poland.
  • Paradziej-Lukowicz J; Tri-City Central Animal Laboratory - Research and Service Centre, Medical University of Gdansk, Debinki 1 Str., 80-211, Gdansk, Poland.
  • Augustin E; Chemical Faculty, Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Narutowicza 11/12 Str., 80-233, Gdansk, Poland.
  • Konopa J; Chemical Faculty, Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Narutowicza 11/12 Str., 80-233, Gdansk, Poland.
  • Mazerska Z; Chemical Faculty, Gdansk University of Technology, Department of Pharmaceutical Technology and Biochemistry, Narutowicza 11/12 Str., 80-233, Gdansk, Poland. Electronic address: zofia.mazerska@pg.edu.pl.
Eur J Med Chem ; 204: 112599, 2020 Oct 15.
Article en En | MEDLINE | ID: mdl-32736230
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / ADN / Diseño de Fármacos / G-Cuádruplex / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / ADN / Diseño de Fármacos / G-Cuádruplex / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2020 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Francia