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Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?
Lam, Yuko P Y; Chiu, Cookson K C; Wootton, Christopher A; Hands-Portman, Ian; Li, Meng; Barrow, Mark P; O'Connor, Peter B.
Afiliación
  • Lam YPY; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
  • Chiu CKC; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
  • Wootton CA; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
  • Hands-Portman I; Department of Life Sciences, University of Warwick, Coventry, UK.
  • Li M; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
  • Barrow MP; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
  • O'Connor PB; Department of Chemistry, University of Warwick, Coventry, UK. p.oconnor@warwick.ac.uk.
Chem Commun (Camb) ; 56(68): 9787-9790, 2020 Aug 25.
Article en En | MEDLINE | ID: mdl-32748913
ABSTRACT
Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipéptido Amiloide de los Islotes Pancreáticos / Agregado de Proteínas / Amiloide Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipéptido Amiloide de los Islotes Pancreáticos / Agregado de Proteínas / Amiloide Límite: Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido