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Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs.
Wilbs, Jonas; Kong, Xu-Dong; Middendorp, Simon J; Prince, Raja; Cooke, Alida; Demarest, Caitlin T; Abdelhafez, Mai M; Roberts, Kalliope; Umei, Nao; Gonschorek, Patrick; Lamers, Christina; Deyle, Kaycie; Rieben, Robert; Cook, Keith E; Angelillo-Scherrer, Anne; Heinis, Christian.
Afiliación
  • Wilbs J; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Kong XD; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Middendorp SJ; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Prince R; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.
  • Cooke A; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.
  • Demarest CT; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
  • Abdelhafez MM; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
  • Roberts K; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.
  • Umei N; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
  • Gonschorek P; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
  • Lamers C; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Deyle K; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Rieben R; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.
  • Cook KE; Department of Clinical Research, University of Bern, CH-3008, Bern, Switzerland.
  • Angelillo-Scherrer A; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
  • Heinis C; Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, Switzerland.
Nat Commun ; 11(1): 3890, 2020 08 04.
Article en En | MEDLINE | ID: mdl-32753636
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Trombosis / Coagulación Sanguínea / Factor XIIa / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Trombosis / Coagulación Sanguínea / Factor XIIa / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido