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Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease.
Saini, Sunil K; Li, Lingyu; Peek, Clara B; Kosmac, Kate; Polonsky, Tamar S; Tian, Lu; Criqui, Michael H; Ferrucci, Luigi; Guralnik, Jack M; Kibbe, Melina; Sufit, Robert L; Leeuwenburgh, Christiaan; McDermott, Mary M.
Afiliación
  • Saini SK; University of Florida, Institute on Aging, Department of Aging and Geriatric Research, Gainesville, FL, United States of America; Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, United States of America.
  • Li L; Northwestern University Feinberg School of Medicine, Department of Medicine, Chicago, IL, United States of America.
  • Peek CB; Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, United States of America.
  • Kosmac K; College of Health Sciences, University of Kentucky Department of Epidemiology, Lexington, KY, United States of America.
  • Polonsky TS; University of Chicago, Department of Medicine, Chicago, IL, United States of America.
  • Tian L; Stanford University, Department of Health Research and Policy, Stanford, CA, United States of America.
  • Criqui MH; University of California at San Diego, Department of Family Medicine and Public Health, San Diego, CA, United States of America.
  • Ferrucci L; National Institute on Aging, Division of Intramural Research, Baltimore, MD, United States of America.
  • Guralnik JM; University of Maryland School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD, United States of America.
  • Kibbe M; University of North Carolina, Department of Surgery, Chapel Hill, NC, United States of America.
  • Sufit RL; Northwestern University Feinberg School of Medicine, Department of Medicine, Chicago, IL, United States of America.
  • Leeuwenburgh C; University of Florida, Institute on Aging, Department of Aging and Geriatric Research, Gainesville, FL, United States of America.
  • McDermott MM; Northwestern University Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, United States of America; Northwestern University Feinberg School of Medicine, Department of Medicine, Chicago, IL, United States of America. Electronic address: mdm608@northwestern.edu.
Exp Gerontol ; 140: 111048, 2020 10 15.
Article en En | MEDLINE | ID: mdl-32755612
OBJECTIVE: This study investigated associations of markers of oxidative stress and mitochondrial function in calf muscle biopsies with walking performance in people with and without lower extremity peripheral artery disease (PAD). METHODS: Participants with PAD (ankle-brachial index (ABI) <0.90) and without PAD (ABI: 0.90-1.50) underwent calf muscle biopsy and measurement of 6-min walk and four-meter walking velocity. PARP1 (Poly (ADP-Ribose) Polymerase 1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), silent information regulator 1 (SIRT1) and 4-hydroxynonenal (4HNE) expression were measured in calf muscle using western blot. RESULTS: Among 15 participants with PAD mean age: 66.8 years (standard deviation (SD): 6.4) and six without PAD (age: 64.4 years, SD: 5.9), mean PARP1-abundance in calf muscle was 1.16 ± 0.92 AU and 0.96 ± 0.38 AU, respectively (P = 0.61). Among participants with PAD after adjustment with ABI, a greater abundance of PARP1 was associated with poorer 6-min walking distance (r = -0.65, P = 0.01), usual-paced 4-m walking velocity (r = -0.73, P = 0.003) and slower fast-paced four-meter walking velocity (r = -0.51, P = 0.07). Among participants with PAD, ABI was not associated with PARP1 abundance in calf muscle (r = 0.02, P = 0.93). Among participants without PAD, skeletal muscle PARP1 abundance was not significantly associated with 6-min walk distance (r = -0.58; P = 0.22), usual-paced walking velocity (r = -0.26; P = 0.62), or fast-paced walking velocity (r = -0.21; P = 0.69), perhaps due to lack of statistical power. There were no associations of remaining calf muscle measures with walking performance. CONCLUSIONS: These findings are consistent with the hypothesis that calf skeletal muscle characteristics are related to walking performance, independently of severity of lower extremity arterial obstruction in people with PAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribosa / Enfermedad Arterial Periférica Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Exp Gerontol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribosa / Enfermedad Arterial Periférica Tipo de estudio: Risk_factors_studies Límite: Aged / Humans Idioma: En Revista: Exp Gerontol Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido