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The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.
Miligy, Islam M; Toss, Michael S; Shiino, Sho; Oni, Georgette; Syed, Binafsha M; Khout, Hazem; Tan, Qing Ting; Green, Andrew R; Macmillan, R Douglas; Robertson, John F R; Rakha, Emad A.
Afiliación
  • Miligy IM; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, The University of Nottingham, Nottingham, UK.
  • Toss MS; Histopathology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
  • Shiino S; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, The University of Nottingham, Nottingham, UK. msxms8@nottingham.ac.uk.
  • Oni G; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, The University of Nottingham, Nottingham, UK.
  • Syed BM; The Breast Institute, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Khout H; Medical Research Centre, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan.
  • Tan QT; The Breast Institute, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Green AR; The Breast Institute, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Macmillan RD; Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, The University of Nottingham, Nottingham, UK.
  • Robertson JFR; The Breast Institute, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Rakha EA; Division of Graduate Entry Medicine, School of Medicine, University of Nottingham Royal Derby Hospital, Derby, UK.
Br J Cancer ; 123(10): 1513-1520, 2020 11.
Article en En | MEDLINE | ID: mdl-32773767
BACKGROUND: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of outcome and the impact on ET decision. METHODS: In total, 643 pure DCIS, diagnosed at Nottingham University Hospitals, were assessed for ER. Clinicopathological data were correlated against ER status, together with assessment of recurrence rate. RESULTS: ER positivity was observed in 74% (475/643) of cases. ER positivity was associated with clinicopathological variables of good prognosis; however, outcome analysis revealed that ER status was not associated with local recurrence. In the intermediate- and high-grade ER-positive DCIS, 58% (11/19) and 63% (15/24) of the recurrences were invasive, respectively, comprising 7% and 6% of all ER-positive DCIS, respectively. Invasive recurrence in low-grade DCIS was infrequent (2%), and none of these patients died of BC. The ER status of the recurrent invasive tumours matched the primary DCIS ER status (94% in ipsilateral and 90% of contralateral recurrence). CONCLUSION: The strong correlation between DCIS and invasive recurrence ER status and the clinical impact of ET justify discussion of the use of ET in ER-positive DCIS treated by breast-conserving surgery. The excellent outcome of low-grade DCIS, which was almost always ER-positive, does not, in the opinion of authors, justify the use of risk-reducing ET. Therefore, the decision on ET for DCIS should be personalised and consider grade, ER status and other characteristics.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma in Situ / Receptores de Estrógenos / Carcinoma Ductal de Mama Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Carcinoma in Situ / Receptores de Estrógenos / Carcinoma Ductal de Mama Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Br J Cancer Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido