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Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population.
Zhou, Xiaopu; Chen, Yu; Ip, Fanny C F; Lai, Nicole C H; Li, Yolanda Y T; Jiang, Yuanbing; Zhong, Huan; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M N; Cheung, Kit; Tong, Estella P S; Ko, Ho; Shoai, Maryam; Mok, Kin Y; Hardy, John; Mok, Vincent C T; Kwok, Timothy C Y; Fu, Amy K Y; Ip, Nancy Y.
Afiliación
  • Zhou X; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Chen Y; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.
  • Ip FCF; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Lai NCH; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Li YYT; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Jiang Y; The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong China.
  • Zhong H; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Chen Y; Hong Kong Center for Neurodegenerative Diseases Hong Kong Science Park Hong Kong China.
  • Zhang Y; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Ma S; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Lo RMN; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Cheung K; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Tong EPS; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Ko H; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Shoai M; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Mok KY; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Hardy J; Guangdong Provincial Key Laboratory of Brain Science Disease and Drug Development HKUST Shenzhen Research Institute Shenzhen-Hong Kong Institute of Brain Science Shenzhen Guangdong China.
  • Mok VCT; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Kwok TCY; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Fu AKY; Division of Life Science State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China.
  • Ip NY; Division of Neurology Department of Medicine and Therapeutics Li Ka Shing Institute of Health Sciences School of Biomedical Sciences Gerald Choa Neuroscience Center Faculty of Medicine The Chinese University of Hong Kong Shatin Hong Kong China.
Alzheimers Dement (Amst) ; 12(1): e12074, 2020.
Article en En | MEDLINE | ID: mdl-32775599
ABSTRACT

INTRODUCTION:

Dozens of Alzheimer's disease (AD)-associated loci have been identified in European-descent populations, but their effects have not been thoroughly investigated in the Hong Kong Chinese population.

METHODS:

TaqMan array genotyping was performed for known AD-associated variants in a Hong Kong Chinese cohort. Regression analysis was conducted to study the associations of variants with AD-associated traits and biomarkers. Lasso regression was applied to establish a polygenic risk score (PRS) model for AD risk prediction.

RESULTS:

SORL1 is associated with AD in the Hong Kong Chinese population. Meta-analysis corroborates the AD-protective effect of the SORL1 rs11218343 C allele. The PRS is developed and associated with AD risk, cognitive status, and AD-related endophenotypes. TREM2 H157Y might influence the amyloid beta 42/40 ratio and levels of immune-associated proteins in plasma.

DISCUSSION:

SORL1 is associated with AD in the Hong Kong Chinese population. The PRS model can predict AD risk and cognitive status in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Alzheimers Dement (Amst) Año: 2020 Tipo del documento: Article
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Idioma: En Revista: Alzheimers Dement (Amst) Año: 2020 Tipo del documento: Article