Effective dose of intravenous oxycodone depending on sex and age for attenuation of intubation-related hemodynamic responses
Turk J Med Sci
; 51(1): 102-110, 2021 02 26.
Article
en En
| MEDLINE
| ID: mdl-32777896
ABSTRACT
Background/aim:
Preoperative intravenous oxycodone may help to prevent or attenuate intubation-related hemodynamic responses (IRHRs), but its pharmacokinetics differs according to age and sex. Therefore, we investigated the 95% effective dose (ED95) of intravenous oxycodone for attenuating all IRHRs, depending on the age and sex of the study population. Materials andmethods:
All patients were allocated to one of 6 groups 1) 2040 year old males, 2) 4165yearold males, 3) 6680 year old males, 4) 2040 year old females, 5) 4165yearold females, and 6) 6680 year old females (groups YM, OM, EM, YF, OF, and EF, respectively). Using Dixon's up-and-down method, the first patient in each group was slowly injected with intravenous oxycodone (0.1 mg kg1) 20 min before intubation. The subsequent patient received the next oxycodone dose, which was decreased or increased by 0.01 mg kg1, depending on the "success" or "failure" of attenuation of all IRHRs to within 20% of the baseline values at 1 min after intubation in the previous patient. After obtaining 8 crossover points, predictive ED95 was estimated with probit regression analysis.Results:
ED95 varied greatly according to age and sex. ED95was 0.133 mg kg1, 0.181 mg kg1, 0.332 mg kg1, 0.183 mg kg1, 0.108 mg kg1, and 0.147 mg kg1in groups YM, OM, EM, YF, OF, and EF, respectively.Conclusion:
ED95 is higher in males with increasing age but is ambiguous for females. ED95 is higher in males than in females over 40 years of age but is higher in females than in males under 41 years of age. However, after considering the age and sex of the study population, these results can be used as reference doses for further studies to verify the clinical effects of oxycodone for attenuating all IRHRs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxicodona
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Anestésicos Intravenosos
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Hemodinámica
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Analgésicos Opioides
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Intubación Intratraqueal
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Laringoscopía
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Turk J Med Sci
Año:
2021
Tipo del documento:
Article