Synthesis of 3,6-Dihydro-2H-1,2-oxazines via Dimethylsulfoxonium Methylide Addition to α,ß-Unsaturated Nitrones.

ABSTRACT

A unique and efficient formation of 3,6-dihydro-2H-1,2-oxazines starting from α,ß-unsaturated nitrones has been achieved. The nucleophilic addition of dimethylsulfoxonium methylide to the C═N bond of an α,ß-unsaturated nitrone to form an aziridine N-oxide followed by the Meisenheimer rearrangement affords 3,6-dihydro-2H-1,2-oxazine in up to 70% yield. Methylene was confirmed to be incorporated at the C3 position of the ring. A wide range of ß-aryl-substituted α,ß-unsaturated nitrones were applicable to this reaction.