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Probing Interactions between Metal-Organic Frameworks and Freestanding Enzymes in a Hollow Structure.
Chen, Sheng-Yu; Lo, Wei-Shang; Huang, Yi-Da; Si, Xiaomeng; Liao, Fu-Siang; Lin, Shang-Wei; Williams, Benjamin P; Sun, Ting-Qian; Lin, Hao-Wei; An, Yuanyuan; Sun, Tu; Ma, Yanhang; Yang, Hsiao-Ching; Chou, Lien-Yang; Shieh, Fa-Kuen; Tsung, Chia-Kuang.
Afiliación
  • Chen SY; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Lo WS; Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
  • Huang YD; Department of Chemistry, National Central University, Taoyuan 32001, Taiwan.
  • Si X; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Liao FS; Department of Chemistry, National Central University, Taoyuan 32001, Taiwan.
  • Lin SW; Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
  • Williams BP; Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
  • Sun TQ; Department of Chemistry, National Central University, Taoyuan 32001, Taiwan.
  • Lin HW; Department of Chemistry, National Central University, Taoyuan 32001, Taiwan.
  • An Y; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Sun T; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Ma Y; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Yang HC; Department of Chemistry, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
  • Chou LY; School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Shieh FK; Department of Chemistry, National Central University, Taoyuan 32001, Taiwan.
  • Tsung CK; Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Nano Lett ; 20(9): 6630-6635, 2020 09 09.
Article en En | MEDLINE | ID: mdl-32786948
ABSTRACT
It has been reported that the biological functions of enzymes could be altered when they are encapsulated in metal-organic frameworks (MOFs) due to the interactions between them. Herein, we probed the interactions of catalase in solid and hollow ZIF-8 microcrystals. The solid sample with confined catalase is prepared through a reported method, and the hollow sample is generated by hollowing the MOF crystals, sealing freestanding enzymes in the central cavities of hollow ZIF-8. During the hollowing process, the samples were monitored by small-angle X-ray scattering (SAXS) spectroscopy, electron microscopy, powder X-ray diffraction (PXRD), and nitrogen sorption. The interfacial interactions of the two samples were studied by infrared (IR) and fluorescence spectroscopy. IR study shows that freestanding catalase has less chemical interaction with ZIF-8 than confined catalase, and a fluorescence study indicates that the freestanding catalase has lower structural confinement. We have then carried out the hydrogen peroxide degradation activities of catalase at different stages and revealed that the freestanding catalase in hollow ZIF-8 has higher activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estructuras Metalorgánicas Idioma: En Revista: Nano Lett Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estructuras Metalorgánicas Idioma: En Revista: Nano Lett Año: 2020 Tipo del documento: Article País de afiliación: China