Your browser doesn't support javascript.
loading
Mitochondrial dynamics in postmitotic cells regulate neurogenesis.
Iwata, Ryohei; Casimir, Pierre; Vanderhaeghen, Pierre.
Afiliación
  • Iwata R; VIB Center for Brain and Disease Research, 3000 Leuven, Belgium.
  • Casimir P; Department of Neurosciences, Katholieke Universiteit (KU) Leuven, 3000 Leuven, Belgium.
  • Vanderhaeghen P; Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium.
Science ; 369(6505): 858-862, 2020 08 14.
Article en En | MEDLINE | ID: mdl-32792401
The conversion of neural stem cells into neurons is associated with the remodeling of organelles, but whether and how this is causally linked to fate change is poorly understood. We examined and manipulated mitochondrial dynamics during mouse and human cortical neurogenesis. We reveal that shortly after cortical stem cells have divided, daughter cells destined to self-renew undergo mitochondrial fusion, whereas those that retain high levels of mitochondria fission become neurons. Increased mitochondria fission promotes neuronal fate, whereas induction of mitochondria fusion after mitosis redirects daughter cells toward self-renewal. This occurs during a restricted time window that is doubled in human cells, in line with their increased self-renewal capacity. Our data reveal a postmitotic period of fate plasticity in which mitochondrial dynamics are linked with cell fate.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Neurogénesis / Células-Madre Neurales / Dinámicas Mitocondriales / Mitocondrias / Mitosis / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Neurogénesis / Células-Madre Neurales / Dinámicas Mitocondriales / Mitocondrias / Mitosis / Neuronas Límite: Animals / Female / Humans / Male Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos